Table 2 Gene ontology pathway terms enriched among the DEG
From: Neural transcriptomic signature of chronic wasting disease in white-tailed deer
Term | DEG (%)1 | Fold Enrichment | P-value2 | |
|---|---|---|---|---|
Biological Process | ||||
GO:0006954 | inflammatory response | 8.6 | 8.2 | < 0.001 |
GO:0007155 | cell adhesion | 7.4 | 6.5 | < 0.001 |
GO:0045087 | innate immune response | 6.9 | 6.2 | 0.001 |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 4.0 | 10.0 | 0.011 |
GO:0019370 | leukotriene biosynthetic process | 2.3 | 41.0 | 0.015 |
GO:0007229 | integrin-mediated signaling pathway | 4.0 | 9.0 | 0.016 |
GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 4.6 | 6.0 | 0.042 |
Cellular Component | ||||
GO:0005887 | integral component of plasma membrane | 14.0 | 3.1 | < 0.001 |
GO:0009986 | cell surface | 8.0 | 3.9 | 0.004 |
GO:0016324 | apical plasma membrane | 5.7 | 5.7 | 0.003 |
GO:0045121 | membrane raft | 5.1 | 6.5 | 0.003 |
GO:0005576 | extracellular region | 7.4 | 3.9 | 0.003 |
GO:0005615 | extracellular space | 11.0 | 2.4 | 0.019 |
GO:0016021 | integral component of membrane | 30.0 | 1.5 | 0.017 |
Molecular Function | ||||
GO:0004497 | monooxygenase activity | 2.9 | 18.0 | 0.034 |
GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 2.9 | 18.0 | 0.034 |
GO:0005506 | iron ion binding | 4.6 | 6.4 | 0.027 |
GO:0005178 | integrin binding | 2.9 | 13.0 | 0.035 |