Fig. 7
From: Transcriptomic profiling implicates PAF1 in both active and repressive immune regulatory networks
Inferred activity of known regulons aligns with motif analysis of PAF1-dependent gene expression. A The normalized enrichment scores (NES) of significantly enriched (p < 0.05) immune (GO: 002376) regulons for ncgRNA cells across stimulations relative to the mock are plotted. These are mapped to their counterpart NES values in PAF1 KO (stimulation versus mock). A paired Wilcoxon signed rank test with Bonferroni correction was performed to assess significant changes between the distributions of normalized enrichment scores. B NES values of selected transcription factors were plotted for ncgRNA and PAF1 KO (stimulation versus mock). The color of each point indicates the NES for the respective immune stimulation, and the shape reflects statistical confidence for that NES value. A paired Wilcoxon signed rank test with Bonferroni correction was performed to assess significant changes between the distributions of normalized enrichment scores for PAF1 KO and ncgRNA. The resultant p-value is listed above each set of boxplots