Table 1 Summary of innate immune stimuli
From: Transcriptomic profiling implicates PAF1 in both active and repressive immune regulatory networks
Stimulus | Type | Target | Effect |
|---|---|---|---|
poly I:C | dsRNA | RIG-I, MDA5, TLR3 | IFN-I production |
poly dA:dT | dsDNA | cytosolic DNA sensors (CDS) | IFN-I production, inflammasome formation |
Lipopolysaccharide (LPS) | G(−) bacteria | TLR4, caspases | Inflammatory cytokine production, inflammasome formation |
Tumor necrosis factor alpha (TNF-α) | inflammatory cytokine | TNFR pathway | Inflammation, apoptosis, NF-κB related pathways |
Interferon-beta (IFN-β) | IFN-I | IFNAR1/2, JAK-STAT cascade | interferon-stimulated gene (ISG) expression |