Fig. 3

Correlation matrices between the gene expression of the two subsets of genes. The correlation matrices were plotted for the R group (n = 18) and the C group (n = 17). The group of differential genes involved in energy metabolism is referred as “Subset 1” and the group of differential genes identified in this study and mostly involved in one carbon metabolism and epigenetic mechanisms is referred as “Subset 2”. The color scale indicates the strength of the correlation; blue for a positive correlation and red for a negative one. Only the significant correlations (with a P-value < 0.05) were plotted. The square represents the correlations between the 16 DEGs of energy metabolism and the 22 differential genes of the one-carbon metabolism and epigenetic mechanisms. The imputed but not qqnorm transformed, normalized relative expressions were used