Fig. 6

Circos visualisation of single nucleotide variants (SNV) candidates indicated allelic bias between pulmonary arteries affected by embolism (PA-E) and control (CTR) libraries. The external circle illustrates porcine chromosomes and other unclassified scaffolds, where region length is proportional to the number of alternative allele substitutions. The genes belonging to the cellular components of the endoplasmic reticulum were marked on the outer track. The second track depicts canonical (A-G, C-T; black) and other types of nucleotides substitutions (grey). The third track (histogram) depicts differences in the alternative allele fraction (ΔAAF) between PA-E and the CTR libraries. In the eight middle scatter plots, RNA editing substitutions are shown as upstream (blue triangles), 5' UTR (red rectangle), missense (yellow circle), synonymous (purple circle), intron (green squares), splice acceptor (grey circle), 3' UTR (orange triangle) and downstream (grey rectangle). Each inner track shows the coverage of alternative (red histogram) and reference variants (green histogram) in all RNA-seq libraries