Selection signatures for local and regional adaptation in Chinese Mongolian horse breeds reveal candidate genes for hoof health

Table 2 Genes with functional significance identified in the selection peaks and flanking regions in the Asian versus American/Middle Eastern horse cohorts

ECA	Region (Mb)	CSS value	Candidate genes	Function
6	82.81–82.81	2.16	MSRB3, LLPH, HELB	Deafness
6	82.81–82.81	2.16	IRAK3, HMGA2, CAND1	Immune response
17	57.06–57.22	1.64	SLITRK6	Deafness
21	2.62–3.62	1.72	IL12RB1, BST2, JAK3, IFI30, UBA52, AP1M1	Immune response
			SLC27A1	Response to cold
			KCNN1, SIN3B	Intellectual Disability
			TMEM59L, NR2F6, MAP1S, NCAN, HAPLN4, CHERP	Nervous system development
			YJEFN3, MRPL34, MPV17L2, GTPBP3, SLC25A42, NWD1, NDUFA13, HSH2D, FAM32A	Mitochondria
			TMEM38A	Muscular Dystrophy
			TPM4	Muscle contraction
			BORCS8	Heart development
			CALR3	Spermatogenesis
27	17.56–17.75	1.754087	SGCZ	Heart contraction
27	17.56–17.75	1.754087	DLC1	Brain development

ISSN: 1471-2164