Fig. 1
From: Sex-biased genetic regulation of inflammatory proteins in the Dutch population
Graphical representation of study cohorts, design and analysis conducted. This study utilized two population-based cohorts (500FG & 300 BCG) of individuals of European decent. Imputed genetic data and plasma protein abundances profiled with the Olink inflammatory panel were available for protein quantitative trait (pQTL) mapping in sex-dependent fashion. The resulting summary statistics were integrated using the meta-analytic approach for males and females separately. Colocalization and functional enrichment analysis of the identified meta-analyzed pQTL variants were conducted. Finally, we cross-validated the identified pQTL variants with previously published molecular traits