Unified mRNA Subcellular Localization Predictor based on machine learning techniques

BMC Genomics

Table 6 UMSLP Results on Independent Dataset - All Locations

Model/Class	Pr	Sn	Acc	Sp	F1
CatBoost
Cytoplasm	0.75	0.87	0.82	0.78	0.80
ER	0.86	0.35	0.93	0.99	0.50
ExR	0.73	0.19	0.95	1.00	0.30
Mitochondria	1.00	0.91	1.00	1.00	0.96
Nucleus	0.81	0.87	0.87	0.87	0.84
Avg	0.83	0.64	0.91	0.93	0.68
XGBoost
Cytoplasm	0.76	0.89	0.84	0.80	0.82
ER	0.93	0.47	0.95	1.00	0.62
ExR	0.84	0.18	0.95	1.00	0.30
Mitochondria	1.00	0.90	1.00	1.00	0.95
Nucleus	0.84	0.89	0.89	0.89	0.86
Avg	0.87	0.67	0.92	0.94	0.71
DT
Cytoplasm	0.69	0.68	0.73	0.77	0.68
ER	0.38	0.43	0.88	0.92	0.40
ExR	0.15	0.12	0.91	0.96	0.13
Mitochondria	0.75	0.63	0.98	0.99	0.68
Nucleus	0.70	0.72	0.77	0.80	0.71
Avg	0.53	0.51	0.85	0.89	0.52
GNB
Cytoplasm	0.61	0.20	0.60	0.91	0.30
ER	0.20	0.51	0.75	0.78	0.29
ExR	0.19	0.30	0.89	0.93	0.23
Mitochondria	0.44	0.96	0.96	0.96	0.60
Nucleus	0.58	0.68	0.68	0.68	0.62
Avg	0.40	0.53	0.78	0.85	0.41
MLP
Cytoplasm	0.78	0.81	0.82	0.83	0.79
ER	0.71	0.59	0.94	0.97	0.64
ExR	0.39	0.17	0.94	0.98	0.24
Mitochondria	0.91	0.86	0.99	1.00	0.88
Nucleus	0.78	0.85	0.85	0.85	0.81
Avg	0.71	0.65	0.91	0.93	0.67
StackEnsemble
Cytoplasm	0.78	0.84	0.83	0.82	0.81
ER	0.75	0.63	0.94	0.98	0.68
ExR	0.63	0.26	0.95	0.99	0.37
Mitochondria	0.92	0.94	1.00	1.00	0.93
Nucleus	0.82	0.85	0.87	0.88	0.84
Avg	0.78	0.70	0.91	0.93	0.72

ISSN: 1471-2164