Fig. 4
From: Distinct regulatory networks control toxin gene expression in elapid and viperid snakes
Predicted cis-regulatory elements in the promoter regions of Pseudonaja textilis three-finger toxins. Only the first 341 bp upstream from the Transcription Initiation Site (TIS) could be evaluated for (A) three-finger toxin (3FTx) pseudonajatoxin b (AY027493) and 684 bp upstream from the TIS for (B) short-chain 3FTxs (AF204969) due to limited sequence availability and fragmented genome assembly. Pseudonaja textilis did not express transcripts encoding non-conventional 3FTxs in the venom gland, despite the presence of a non-conventional 3FTx gene in its genome (XP_026561523). From the genome reference, 713 bp upstream from what would be the TIS for this (C) non-conventional 3FTx was evaluated. Fold-changes in expression levels are shown between the P. textilis milked venom gland and unmilked venom gland for trans-factors known to interact with predicted cis-regulatory elements (CREs). CRE predictions were completed with the online server AliBaba2.1 using the TRANSFAC 4.0 database. CREs shared across panels are bolded red. Photo credit: P. textilis, Ákos Lumnitzer