Fig. 1

HPV16 complex integrated genome structure in SiHa cells. In the top panel, the colored regions in the outer circle represent the HPV16 sequences contained within the integrated structure, while the white regions represent the sequences that were replaced or lost as a result of integration. The inner circle shows the complete HPV16 genome for reference. The bottom panel illustrates the HPV and human reference genomes, which are connected by dotted lines to a contig that covers the integration, demonstrating how it specifically mapped to each genome(1, 2, 3, and 4 represent breakpoints on the HPV16 genome; 1a and 2a represent breakpoints on human chromosome 13; F1, F2, F3, F4, F5 represent consecutive segments on human chromosome 13). Schematic annotations of the integration event were made using data from all PacBio long reads that covered the integration event