Fig. 2

HPV18 complex integrated genome structure in HeLa cells. A, B Two proposed models of HPV18 integration genome structure in HeLa cells. In the top panel, two proposed HPV18 integration genome structures in HeLa cells are depicted. The colored regions in the outer circle represent the HPV18 sequences contained within the integrated structure, while the white regions represent the sequences that were replaced or lost as a result of integration. The inner circle shows the complete HPV18 genome for reference. The bottom panel illustrates the HPV and human reference genomes, which are connected by dotted lines to a contig that covers the integration, demonstrating how it specifically mapped to each genome. Schematic annotations of the integration event were made using data from all PacBio long reads that covered the integration event