Fig. 10

Integrated data analysis identified that Srebf1 plays a central role in mediating adrenarche-accompanied androgens to prevent NAFLD in young females. A Most of the key DEGs involved in lipid biosynthetic process/fatty acid oxidation are with putative SREBF1 binding sites within their promoter regions. Promoter regions spanning 1500 bp upstream and 500 bp downstream of the transcription start site were scanned using CiiiDER software. B The putative mechanism by which adrenarche-accompanied androgens in pre-venting NAFLD in young females