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Fig. 9 | BMC Genomics

Fig. 9

From: Adrenarche-accompanied rise of adrenal sex steroid precursors prevents NAFLD in Young Female rats by converting into active androgens and inactivating hepatic Srebf1 signaling

Fig. 9

Overlapping analysis identifies key genes in mediating adrenarche-accompanied androgens to prevent NAFLD in young female rats during adrenarche. A The common regulated DEGs by flutamide in comparison to vehicle or DHT. B Network analysis identified key terms and key DEGs involved in liver fat metabolism regulated by active androgens. C qPCR validation of the selected key DEGs involved in fatty acid biosynthesis/oxidation. Different letters indicate p < 0.05. Srebf1, sterol regulatory element-binding tran-scription factor 1; Acly, ATP citrate lyase; Acaca, acetyl-CoA carboxylase alpha; Fasn, fatty acid synthase; Elovl6, ELOVL fatty acid elongase 6; Scd1, stearoyl-Coenzyme A desaturase 1; Cpt1a, carnitine palmitoyltransferase 1 A; Ppara, peroxisome proliferator activated receptor alpha

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BMC Genomics

ISSN: 1471-2164

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