Fig. 3

Volcano plot of differentially expressed genes (DEGs) in the SV subtype cells from mice with sensorineural hearing loss and bar chart of gene set enrichment analysis (GSEA) of these DEGs. DEG analysis of IC (A), BC (C) and MC (E) from age-related hearing loss (ARHL), noise-related hearing loss (NRHL), and cisplatin-related hearing loss (CRHL) datasets compared with the adult dataset are shown in volcano plot. The top ten genes in the volcano plot have been labeled, with log2FC cutoff set at 0.5 and p-value cutoff set at 0.001. DEGs in SV cells from the ARHL (B), NRHL (D), and CRHL (F) datasets compared with the adult dataset are clustered using GSEA on WebGestalt 2019. These genes clustered in the oxidative phosphorylation and electron transport chain pathways with GSEA analysis are colored in the electron transport chain from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database (G). IC, intermediate cells; BC, basal cells; MC, marginal cells, SV, stira vascularis