Transcriptomic divergence of the Rheum palmatum complex derived from top-geoherb and non-geoherb areas provides the insights into geoherbalism properties of rhubarb

Table 2 Candidate genes involved in the biosynthesis of anthraquinones of R. palmatum complex

Pathway	Gene name	Enzyme symbol	KO number	No
MVA	Acetyl-CoA C-acetyltransferase	AACT	K00626	14
	Hydroxymethylglutaryl-CoA synthase	HMGS	K01641	10
	Hydroxymethylglutaryl-CoA reductase	HMGR	K00021	21
	Mevalonate kinase	MK	K00869	4
	Phosphomevalonate kinase	PMK	K00938	3
	Diphosphomevalonate decarboxylase	MPD	K01597	6
	Isopentenyl-diphosphate Delta-isomerase	IPPs	K01823	10
MEP	1-deoxy-D-xylulose-5-phosphate synthase	DXS	K01662	9
	1-deoxy-D-xylulose-5-phosphate reductoisomerase	DXR	K00099	2
	2-C-Methyl-D-erythritol 4-phosphate cytidylyltransferase	ISPD	K00991	1
	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	CDPMEK	K00919	1
	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ISPF	K01770	2
	(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase	HDS	K03526	5
Shikimate	4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase	HDR	K03527	3
	3-deoxy-7-phosphoheptulonate synthase	DAHPS	K01626	13
	3-dehydroquinate synthase	DHQS	K01735	4
	3-dehydroquinate dehydratase / shikimate dehydrogenase	SDH	K13832	12
	Shikimate kinase	SMK	K00891	8
	3-phosphoshikimate 1-carboxyvinyltransferase	EPSPs	K00800	6
	Chorismate synthase	CS	K01736	13
	Menaquinone-specific isochorismate synthase	IS	K02552	2
	Isochorismate synthase	MenF	K14759	0
	2-succinylbenzoate–CoA ligase	MenE	K14760	1
	Naphthoate synthase	MenB	K01661	3
Polyketide	Type III polyketide synthase	PKS III	K00660	26
Glycosylation	UDP-Glucosyl Transferase	UGT	_	118
CYP450s	Cytochrome P450	_	_	256
CYP450s	NADPH-cytochrome P450 reductase	_	_	32

ISSN: 1471-2164