Fig. 2

The significantly overrepresented pathways identified by enrichment analysis of differentially expressed genes. A and B The top 10 representative GO biological process terms of HMGB1-regulated genes. X-axis represents the base 10 logarithm of the enrichment p-value, y-axis represents the term of enriched GO pathways. Up means up-regulated genes in OE-HMGB1 cells, down means down-regulated genes in OE-HMGB1 cells. C Heatmap of transcription factor genes in control and HMGB1-OE cells. In the heatmap, colors ranged from blue to red, correspond to low-to-high expression level in cells. D Validation of some DEGs by identical RT-qPCR assay