Fig. 4

Comparison of N-MYC and PDPK1 regulated genes. (a) Venn diagram showing the overlap of N-MYC regulated genes as determined by OmoMYC induction in Fig. 1 and PDPK1 regulated genes as determined by depletion of PDPK1 in Fig. 3. (b) Gene enrichment analysis for the 403 genes in (a) that are commonly suppressed by inhibition of N-MYC and PDPK1 using ShinyGO, GO: Biological Process or (c) ShinyGO, GO: Cellular Component. (d) Gene enrichment analysis for the 676 genes in (a) that are commonly induced by N-MYC and PDPK1 using ShinyGO, GO: Biological Process or (e) ShinyGO, GO: Cellular Component. (f) Venn diagram showing the overlap of the 403 genes commonly suppressed by inhibition of N-MYC and PDPK1 compared to N-MYC bound genes detected previously in CHP-134 cells using ChIP-seq [14]. Gene ontology analysis of the 218 N-MYC targets is shown as a network below the overlap region to emphasis gene categories observed