Fig. 5
From: Common occurrence of hotspots of single strand DNA breaks at transcriptional start sites
Closer proximity of template strand SSB hotspots is associated with higher gene expression. Box plots of the expression levels (log2(TPM + 1), Y-axes) of genes that contain sample-shared (depth ≥ 1) hotspots of AP sites (A) and SSBs (B) within the indicated non-overlapping bins (X-axes) near their TSSs on the template or non-template strands in at least one tissue. Box plots indicate median (middle line), 25th, 75th percentile (box) and 1.5× interquartile range (whiskers) as well as outliers (single points). The asterisks above the horizontal lines denote the significance of the difference: *, **, *** represent respectively p-values < 0.05, 0.01 and 0.001 (Wilcoxon Rank Sum Test), while “ns” mean no significant difference. See Supplemental Tables 6 and Methods for more details