Table 3 Two novel loci associated with TILs identified from Discovery GWAS and Meta-analyses with p < 5 × 10− 6
From: Germline genetic regulation of the colorectal tumor immune microenvironment
RS ID: CHR: BP | Nearest Gene | Loci | EFF/REF alleles* | Discovery (MECC) | Replication (Harvard Cohorts) | Replication (CLX) | Meta Analysis Results | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EAF** | OR (95% CI)*** | p | EAF | OR (95% CI) | p | EAF | OR (95% CI) | p | EAF | OR (95% CI) | p | PHeterogeneity | ||||
rs10982853:9:118405173 | RP11-284G10.1 | 9q33.1 | C/T | 0.87 | 1.47 (1.25–1.72) | 2.71E-06 | 0.87 | 1.22 (0.79–1.89) | 0.3646 | 0.88 | 1.07 (0.40–2.83) | 0.8928 | 0.87 | 1.43 (1.23–1.65) | 2.85E-06 | 0.6272 |
rs215529:20:2767620 | RPL19P1 | 20p13 | C/T | 0.57 | 0.77 (0.69–0.86) | 1.53E-06 | 0.61 | 0.89 (0.66–1.19) | 0.4238 | 0.54 | 1.33 (0.66–2.69) | 0.4244 | 0.57 | 0.79 (0.72–0.87) | 3.58E-06 | 0.2329 |