Fig. 4

Copy number heatmaps of the SA501, HGSC and NCI-N87 datasets. Copy numbers of cells in fix-sized genomic bins are compared between distinct cell subpopulations (rows correspond to the cells and columns refer to the genomic bins). The colors represent different copy numbers. A Copy number heatmap of SA501 shows there are many small-sized regions across the chromosomes that have different copy numbers in subpopulation 1 compared to subpopulations 2 and 3. The differences between subpopulations 2 and 3 are mainly observed on chromosome 11. B Copy numbers of OV2295R (clones 1–2) and TOV2295R (clones 3–4) cell lines are significantly different, and there are also minor differences in copy numbers between cell subpopulations of the same cell line. C Copy number heatmap of NCI-N87 dataset. There are significant differences between the copy number profiles of distinct subpopulations. Chromosome information of the bins is not available for this dataset